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The epidemiology of gastric cancers in the era of Helicobacter pylori eradication: A nationwide cancer registry-based study in Taiwan

Cancer Epidemiology, Biomarkers & Prevention Sep 12, 2019

Chang JS, Kuo SH, Chu PY, et al. - Using data from the Taiwan Cancer Registry, researchers performed a comprehensive assessment of the incidence trend and survival of gastric cancer in Taiwan by histologic subtype between 1996 and 2013. In 1996, the incidence of all gastric cancers in Taiwan was estimated to be 15.97 per 100,000; however, this value reduced to 11.57 per 100,000 in 2013. Adenocarcinoma was documented as the most prevalent histologic subtype of gastric cancer in Taiwan, followed by lymphoma and sarcoma (mainly gastrointestinal stromal tumor). Patients with sarcoma experienced the best survival, followed by those with lymphoma, neuroendocrine tumor, and adenocarcinoma. Generally, better survival was experienced by women vs men. In 1996, the incidence of adenocarcinoma was estimated to be 13.56 per 100,000, but this value fell significantly to 9.82 per 100,000 in 2013. In contrast, no reduction was reported in the incidences of mucosa-associated lymphoid tissue lymphoma and diffuse large B-cell lymphoma. Findings revealed diverging trends of the incidence of adenocarcinoma and lymphoma, both of which are related to Helicobacter pylori. Differences were found in the survival of gastric cancer by histologic subtype and sex.

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