Beale AL, Cosentino C, Segan L, et al. - Researchers investigated the correlation between prior parity with the rest and exercise hemodynamic and echocardiographic profile of women with heart failure with preserved ejection fraction (HFpEF). They performed the inclusion of patients who were referred for assessment of exertional dyspnoea and were confirmed to have a hemodynamic and clinical profile consistent with HFpEF. Assessment of 58 was done; these were categorized as having either 0–2 births or ≥ 3 births, dividing the cohort equally. Women with higher parity exhibited greater impairments in multiple physiologic parameters of HFpEF severity, including diastolic reserve, pulmonary vascular resistance, and systolic dysfunction. Findings thus indicate the role of repeated pregnancies in the development and severity of HFpEF, distinguishing multiparous women as targets for preventative and early therapeutic measures, and may aid to explain the overrepresentation of women in the HFpEF population.