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The effect of hypoglycaemia during hospital admission on health-related outcomes for people with diabetes: A systematic review and meta-analysis

Diabetic Medicine Aug 29, 2019

Lake A, et al. - The researchers carried out a systematic review and meta-analysis to evaluate the health-related outcomes of hypoglycaemia among people with diabetes admitted to hospital, particularly, hospital length of stay and mortality. Fifteen studies relating to hypoglycaemia (< 4 mmol/l) for hospitalized adults (≥ 16 years) with diabetes reporting the primary outcomes of interest, hospital length of stay or mortality were included. Compared with those without hypoglycaemia, the pooled mean difference in length of stay for ward-based inpatients exposed to hypoglycaemia was 4.1 days longer. This connection remained strong across the prespecified subgroup analyses. An association was found between inpatient hypoglycaemia and longer length of stay and greater in-hospital mortality. Studies investigating this connection in terms of both clinical populations and effect size were heterogeneous, but the association's overall direction was consistent. Glucose concentration should, therefore, be considered as a potential tool to help identify patients at risk of poor health-related outcomes.
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