Yu J, Feng J, Jin T, et al. - In this randomized controlled clinical trial, researchers compared the safety and effectiveness of conjunctival autograft (CAG), amniotic membrane transplantation (AMT) with postoperative interferon alpha-2b (IFN alpha-2b) and modified conjunctival autograft plus amniotic membrane transplantation (mCAG+AMT) with postoperative IFN alpha-2b for primary pterygium. For this analysis, eyes with nasal and primary pterygia were randomized in a 1:1:1 ratio to obtain CAG, or AMT with IFN alpha-2b, or mCAG+AMT with IFN alpha-2b. Eighty-five individuals (30 in CAG group, 25 in AMT group, 30 in CAG+AMT group) completed the 12-month follow-up. No complication or grade 4 recurrence has been reported. In the report, all three strategies presented good protection and clinical efficacy. The two surgeries using no autograft or minimal autograft were less traumatic compared with conjunctival autograft, providing greater flexibility for future ocular surface condition change.