Tulloch JSP, Semper AE, Brooks TJG, et al. - Through an ecological study of regularly collected laboratory surveillance data of 3,986 laboratory-confirmed cases of Lyme disease between 2013 and 2016, researchers characterized the demographics and distribution of laboratory-confirmed cases of Lyme disease from a national testing laboratory. From 1.62 cases to 1.95 per 100,000 in 2013 and 2016, respectively, the incidence of laboratory-confirmed Lyme disease increased significantly over the study period in England and Wales. A bimodal age distribution (peaks at 6–10 and 61–65 years age bands) impacting mostly men was noted. With more cases noted in less deprived areas, a relationship among disease incidence and socioeconomic status was observed. In rural areas, cases were disproportionately seen vs the national population distribution. Therefore, Lyme disease patients are more likely to come from areas with greater socioeconomic status and rural areas. Moreover, recognition of Lyme disease hotspots in southern England, along with the socio-demographics described, would facilitate a targeted strategy to public health interventions and messages.