An J, et al. - Given that familial clustering represents a common characteristic of, and a risk factor for, hepatocellular carcinoma (HCC), researchers determined the impact of such a family history on prognostic results in patients with HCC diagnosed at various stages of the disease in this hospital registry-based cohort study. Participants were 5,484 patients among whom HCC was initially diagnosed. They observed a significant trend showing the link between the increasing number of affected family members and the attenuated risk of mortality. In the subset of patients with HCC at a (very) early stage, the presence of family history was particularly found to be related to an attenuated risk of mortality in the stage-stratified analysis. Early-stage patients with a family history exhibited a higher proportion of cases taking curative therapy. Findings revealed a first-degree family history of the disease as a prognostic factor for improved survival in patients with HCC, particularly in those whose tumors can be cured by radical treatments.