Dolz-Marco R, et al. - In an eye with macular atrophy due to age-related macular degeneration (AMD; complete retinal pigment epithelium (RPE) and outer retinal atrophy (cRORA)), experts correlated the in vivo imaging to histology to ascertain the atrophy border and assess the utility of optical coherence tomography (OCT) metrics suggested by previous histology. The external limiting membrane (ELM) descent is a histopathologic atrophy border supporting new terminology of cRORA, whereas hypertransmission reveals RPE degeneration; as is seen on ELM. They confirmed the RPE-BLamD thickening across the macula, towards the atrophy and over time. In disease progression, macular atrophy is a late stage; suggested by the presence of gliosis and thick RPE-BLamD. This encourages the anatomical endpoints at earlier AMD stages, rather than atrophy enlargement.