Corkum KS, et al. - Given that testicular tissue cryopreservation (TTC) provides an experimental option for fertility preservation for male children at significant risk for azoospermia owing to high-risk gonadotoxic treatments, researchers retrospective reviewed 23 TTC cases (5 months to 18 years) who underwent a unilateral wedge biopsy of the testis for TTC in this single institution study. The cases were diagnosed with solid tumor (74%, n = 17), hematologic malignancy (17%, n = 4), or benign hematologic disease (13%, n = 3). Outcomes suggest that for TTC, testicular wedge biopsy can be performed safely, coordinated with other necessary procedures, in addition to leading no delay in the start of treatment. Given no reports of spermatogenic recovery or pregnancies from cryopreserved testicular tissues, TTC remains an experimental option for fertility preservation for children.