van der Hoeven NW, et al. - Researchers investigated if hemodynamic indices in nonculprit vessels have any significance in 73 patients with ST-segment elevation myocardial infarction (STEMI) from the index event to 1-month follow-up. Patients had increased nonculprit fractional flow reserve and decreased coronary flow reserve in the acute setting. A numerical increase was observed in instantaneous wave-free ratio but it stayed stable from the acute moment of presentation to 1-month follow-up. They noted an increased hyperemic and decreased baseline microcirculatory resistance in the acute setting of STEMI along with these changes. Patients with STEMI have alterations in intracoronary hemodynamics in the acute setting that correlate with the value of nonculprit intracoronary physiologic indices essential to guide revascularization of intermediate stenoses.