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Telomere length and vascular phenotypes in a population-based cohort of children and midlife adults

Journal of the American Heart Association Jun 05, 2019

Nguyen MT, et al. - In this population-based cross-sectional CheckPoint (Child Health CheckPoint) study nested within the Longitudinal Study of Australian Children, researchers examined children and midlife adults, focusing how telomere length correlates with vascular structure and function. By means of quantitative polymerase chain reaction from blood-derived genomic DNA, they measured telomere length. They found some evidence for a link of telomere length with vascular elasticity, but not thickness, in midlife adults, but not in children. A possibility that links between telomere length and cardiovascular phenotypes become more evident later in life, with advancing pathological alterations, was also suggested.

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