Nyamathi AM, et al. - Researchers conducted a quasi-experimental trial of a comprehensive Accredited Social Health Activist (Asha)-supported intervention comparing 4 distinct Asha-based programs [(1) standard education (SE) alone; (2) nutrition education (+NE); (3) nutrition supplements (+NS); or (4) nutrition education and nutrition supplements (+NENS)] regarding key disease and nutrition-related outcomes [CD4 count, body mass index (BMI), serum albumin, and hemoglobin]. They enrolled 600 Women living with HIV (WLH; n = 150 per arm). At 18-month follow-up, program 4 (+NENS) vs program 1 (+SE) experienced greatest improvements in CD4 counts. For BMI, programs 3 (+NS) and 4 (+NENS) vs program 1 (+SE) manifested greater gains. They also noted an improvement in hemoglobin and serum albumin over time; program 4 (+NENS) exhibited the greatest gains. These findings support the efficacy of a low-cost Asha-supported behavioral and nutritional intervention for improving outcomes for WLH. HIV and other infectious disease-related outcomes in vulnerable populations could be improved via similar approaches.