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Strongyloides stercoralis coinfection is associated with greater disease severity, higher bacterial burden and elevated plasma matrix metalloproteinases in pulmonary tuberculosis

The Journal of Infectious Diseases Apr 23, 2020

Kumar NP, Kathamuthu GR, Moideen K, et al. - Researcher sought to determine the influence of helminth infections on disease severity and bacterial burdens in tuberculosis (TB). A cohort of pulmonary TB (PTB) individuals with (Ss+) vs without (Ss-) seropositivity for Strongyloides stercoralis infection was assessed for the disease severity. Increased risk of cavitation and bilateral lung involvement were observed in correlation with Ss+ in PTB individuals. Per data gained, coexistent Ss infection is linked with greater disease severity and higher bacterial burden in PTB. Further, the data revealed that coinfected individuals exhibit enhanced plasma levels of matrix metalloproteinases, indicating a plausible biological mechanism for these effects.

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