Bringmann A, et al. - In this retrospective case series, researchers documented with spectral domain optical coherence tomography the formation and spontaneous closure of small full-thickness macular holes and proposed the active role of Müller cells in macular hole closure. The sample consisted of five patients with spontaneous closure of macular holes. Foveal images were recorded over a period of 18 months in one patient. It is proposed that the spontaneous closure of small macular holes and the subsequent reconstruction of the normal foveal structure are mediated by Müller cells' active mechanisms that mimic those involved in ontogenetic foveal formation.