Enzan N, et al. - Researchers examined if patients with heart failure (HF) with mid-range ejection fraction (HFmrEF) exhibit better long-term outcomes in association with the discharge use of spironolactone. The Japanese Cardiac Registry of Heart Failure in Cardiology yielded data of a total of 457 patients who had HFmrEF; mean age 69.3 years and 286 (62.6%) male. Among these, 158 patients (34.6%) were prescribed spironolactone. Discharge use of spironolactone was noted to be independently correlated with better long-term outcomes. Patients with spironolactone had a lower prevalence of chronic kidney disease and were more often prescribed loop diuretics. These findings suggest a possible utility of spironolactone for patients with HFmrEF.