Souied EH, Addou-Regnard M, Ohayon A, et al. - Via retrospectively involving patients with neovascular age-related macular degeneration (nAMD) when macular subretinal fibrosis was present, researchers described the spectral-domain optical coherence tomography (OCT) features of fibrotic lesions associated with nAMD and illustrated the progression pathways from initial macular choroidal neovascular lesions (CNVs) to fibrosis. Fibrosis was categorized by spectral-domain OCT for retinal pigment epithelium (RPE) in 836 spectral-domain OCT slices of 44 eyes in 39 patients. Also, 4,181 spectral-domain OCT slices have been retrospectively reviewed in 47 distinct eyes to determine longitudinally progression from the initial lesion to the final fibrosis. This spectral-domain OCT analysis detected different patterns of macular fibrosis in eyes with nAMD. Three pathways of fibrosis progression have been described, including the well-established pathway of type 2 CNV progression to fibroglial lesion (FGL) and the progression of type 1 fibrovascular CNV to FGL or fibroatrophic lesion.