Klimas J, et al. - In this systematic review and meta-analysis of randomized, controlled trials (RCTs), researchers evaluated the effectiveness of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD). For this investigation, RCTs of all durations were included that evaluated the impact of SROM on measures of treatment retention, heroin use, and craving in adults who met the diagnostic criteria for OUD. Findings suggested that SROM may be similar to methadone in retaining patients in treatment and decreasing heroin use while potentially leading to less craving. The included RCTs were low-to-moderate in methodological quality.