Lam PH, et al. - This study was designed to assess associations of below-target and target dose of enalapril with outcomes in patients with heart failure and reduced ejection fraction (HFrEF) in the Studies of Left Ventricular Dysfunction (SOLVD) Treatment trial. It appeared that clinical benefits of angiotensin-converting enzyme (ACE) inhibitors were similar at both below-target and target doses in these subjects.