Salvatore JE, Barr PB, Stephenson M, et al. - Researchers investigated how polygenic scores for educational attainment are associated with clinical criterion counts for three substance use disorders (SUDs; alcohol, nicotine, and cannabis). They used polygenic association and sibling comparison methods to perform this study at six sites in the United States. From the Collaborative Study on the Genetics of Alcoholism, European ancestry participants aged 25 years and older were assessed. Five thousand five hundred eighty-two (54% female) participants were included in polygenic association analyses and 3,098 (52% female) participants from 1,226 sibling groups nested within the overall sample were included in sibling comparisons. As per analysis, fewer clinical criteria for alcohol, nicotine, and cannabis use disorders are likely to be met by individuals who carry more alleles associated with educational attainment, and these effects are robust to rigorous controls for potentially confounding factors that differ between families (eg, socio-economic status, urban-rural residency, and parental education).