Novotny V, Khanevski AN, Bjerkreim AT, et al. - Researchers performed a comparison of patients with acute cerebral infarcts in multiple arterial territories (MACI: defined as at least 2 acute cerebral ischemic lesions in at least 2 arterial cerebral territories) vs patients having acute cerebral infarct(s) in a single arterial territory with respect to their in-hospital complications and short-term outcome, namely National Institutes of Health Stroke Scale and modified Rankin Scale at day 7 after admission or at discharge when earlier. Among 3,343 patients with diffusion-weighted imaging-confirmed acute cerebral infarcts, 311 patients (9.3%) had MACI. Patients with MACI exhibited higher National Institutes of Health Stroke Scale and modified Rankin Scale. Patients with MACI more frequently had deep venous thrombosis, myocardial infarction, and in-hospital complications, which may adversely affect short-term clinical and functional outcomes. Such events and negative progression could be prevented using closer follow-up of patients with MACI during hospitalization.