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Short term optimization of glycaemic control using insulin improves sympatho-vagal tone activities in patients with type 2 diabetes

Diabetes Research and Clinical Practice Oct 09, 2019

Mba CM, Nganou-Gnindjio CN, Azabji-Kenfack M, et al. - In this single arm open label clinical trial, researchers identified the short term impacts of optimizing glycaemic control in T2D patients using insulin on the heart rate variability (HRV). Participants in the study were poorly controlled non-insulin treated T2DM patients (HbA1c ≥ 7%). The study sample consisted of 29 consenting T2DM patients (median age was 52[43-59] years) without clinical signs of cardiac autonomic neuropathy and allocated to intervention. Optimizing glycaemic function using a basal plus insulin regimen thus causing a significant reduction in glycated hemoglobin significantly improves sympathetic and parasympathetic activities resulting from the 24-hour ambulatory ECG. This suggests that in patients with T2DM, tight glycaemic regulation using insulin can reverse cardiac autonomic neuropathy.
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