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Short‐term variability of the QT interval can be used for the prediction of imminent ventricular arrhythmias in patients with primary prophylactic implantable cardioverter defibrillators

Journal of the American Heart Association Nov 27, 2020

Smoczyńska A, Loen V, Sprenkeler DJ, et al. - Researchers investigated if imminent ventricular arrhythmias in patients could be predicted by short‐term variability of the QT interval (STVQT). As part of the EU‐CERT‐ICD (European Comparative Effectiveness Research to Assess the Use of Primary Prophylactic Implantable Cardioverter Defibrillators) study, 24‐hour ECG Holter recordings were collected in 2,331 patients with primary prophylactic implantable cardioverter defibrillators. Prior to nonsustained ventricular arrhythmia, nonsustained ventricular tachycardia, and sustained ventricular tachycardia, a rise in STVQT was noted from 0.80 ± 0.43 ms to 1.18 ± 0.78 ms, from 0.90 ± 0.49 ms to 1.14 ± 0.70 ms, and from 1.05 ± 0.22 ms to 2.33 ± 1.25 ms. This increase in STVQT was shown to be significantly higher in sustained ventricular tachycardia vs nonsustained ventricular arrhythmia and vs nonsustained ventricular arrhythmia. Overall, findings revealed increase of STVQT before imminent ventricular arrhythmias in patients, and the extent of the rise was found to be related to the severity of the ventricular arrhythmia.

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