Pighi M, et al. - Researchers performed a preplanned analysis of the FRAILTY-AVR study (Frailty Aortic Valve Replacement; a multinational, prospective, observational cohort at 14 institutions in North America and Europe from 2012 to 2017) to investigate the determinants of outcomes in older women and men undergoing transcatheter aortic valve replacement. The cohort was comprised of 340 women and 419 men. Women were older, had higher predicted mortality risk, higher likelihood of physical frailty traits, but not cognitive or psychosocial frailty traits, and were more likely to require discharge to a rehabilitation facility, especially those with physical frailty at baseline, although their functional status was comparable to men at 12 months. Regardless of sex, global indices of frailty were equally associated with adverse events. Especially in those treated with larger prostheses, they noted greater risk of 1-month mortality or major morbidity in women. With the exception of those with pulmonary hypertension, they observed no greater risk of 12-month mortality in women; those with pulmonary hypertension had a significant risk for increased mortality.