Lu DY, Ventoulis I, Liu H, et al. - Researchers investigated if gender-specific variations in mortality observed in hypertrophic cardiomyopathy (HCM) could be attributable to an older age of women at presentation, or if women have greater degree of left ventricle (LV) myopathy compared with men. In an overall cohort including 728 HCM patients, and an age-matched subgroup involving 400 age-matched patients, clinical/imaging features and results were retrospectively compared between women and men. In the overall cohort, women were older by 6 years. Findings revealed that contributors to a higher, age-independent risk of diastolic heart failure in women with HCM were gender-specific variations in LV geometry, hyper-contractility and diastolic function, not greater degree of LV myopathy.