Zhou Y, Yu M, Yuan J, et al. - Researchers investigated if there exists an influence of systemic hypertension on hypertrophic obstructive cardiomyopathy (HOCM) and if gender-associated disparities exist in this influence. Participants were 453 HOCM patients (age 48.7 ± 12.8 years, 252 [55.6%] males). Patients with a history of controlled systemic hypertension were 150 in total, inducing 81 men and 69 women. All participants were examined via cardiac magnetic resonance imaging. They defined left ventricular (LV) remodeling index (LVRI) > 1.3 g/mL as pathological LV remodeling. Significantly greater LVRI and LVRI > 1.3 g/mL were detected in men vs women. HOCM with hypertension vs those without hypertension demonstrated a significantly lower incidence of syncope and 5-year sudden cardiac death risk score. In men with hypertension, but not in women with hypertension, significantly smaller LVRI and LVRI > 1.3 g/mL were identified. Hypertension continued to be an independent determinant of pathological LV remodeling in men, whereas not in women, as shown in the multivariable logistic analysis. Overall, findings revealed significant gender disparities in the influence of systemic hypertension on LV remodeling among patients with HOCM. In men with HOCM, but not in women, controlled systemic hypertension may add to improving LV remodeling.