Ochoa-Jimenez R, et al. - Researchers performed this study on patients enrolled in the Systolic Blood Pressure Intervention Trial (SPRINT) to evaluate benefit-risk tradeoffs by sex of different blood pressure goals after propensity score matching those with standard therapy (systolic blood pressure [BP] < 140 mmHg) to those with intensive therapy (systolic BP < 120 mmHg). Focusing on the composite outcome of myocardial infarction, other acute coronary syndromes, stroke, heart failure, or death from cardiovascular causes, they performed Cox regression to compare standard vs intensive therapy in women and men. They found no benefit of intensive BP control in women, which may be explained by the lower baseline cardiovascular risk in women. Intensive therapy vs standard therapy in men resulted in a lower risk of the composite outcome.