Marques EA, et al. - Experts evaluated the within and between sex spatial differences in proximal femoral bone characteristics in relation to incident hip fracture using data-driven computational anatomy approaches. In both men and women, an association of the superior aspect of the femoral neck and the trochanteric region (except for cortical bone thickness) with incident hip fracture was seen. Similar trends were followed by differences in bone properties between noncases and incident hip fracture cases. These differences were located at compatible regions and manifested heterogeneity in the spatial distribution of their magnitude with focal regions showing larger differences. As per data, by providing unique information about the specific patterns of bone deterioration associated with incident hip fracture and their sex differences, highlighting the importance of looking to men and women separately in the assessment of hip fracture risk the value of these image analysis techniques was indicated.