Foldyna B, et al. - Given that women compared to men display a higher HIV-attributable risk of myocardial infarction (MI) in high-resource settings, researchers investigated the extent to which unique mechanisms contribute to MI risk among women vs men with HIV. They performed a comparison of subclinical coronary atherosclerotic plaque characteristics—including high-risk morphology plaque features—among 48 HIV-infected women [48 (41, 54) years] and 97 HIV-infected men [48 (42, 52) years] on stable antiretroviral therapy (ART) without known cardiovascular disease. Findings revealed a lower prevalence and burden of subclinical coronary plaque and high-risk morphology plaque among ART-treated HIV-infected women (vs HIV-infected men). Thereby suggesting unique sex-specific mechanisms beyond subclinical plaque to drive the higher HIV-attributable risk of MI among women vs men.