Phan HT, Blizzard CL, Reeves MJ, et al. - Since women are reported to have a poorer health-related quality of life (HRQoL) after stroke, but the underlying reasons are uncertain, researchers investigated factors that contribute to the gender differences. From 4 high-quality population-based incidence studies from Australasia and Europe, individual participant data on 4,288 first-ever strokes (1996–2013) were collected. After a stroke, women consistently displayed poorer HRQoL than men. This was partly attributable to the advanced age of women, more severe strokes, prestroke dependence, and poststroke depression, suggesting differences reduction targets. There was some proof of residual gender differences in HRQoL, but they were tiny and unlikely to be clinically meaningful.