Humphries KH, et al. - Authors conducted this work to assess whether cardiac troponin (cTn) levels by chest pain features modify sex differences in diagnosis, treatment and outcomes in patients presenting with chest pain suggestive of ischemia. Differences in chest pain features or levels of cTn seemed not explaining the sex differences in diagnosis and treatment after presentation to the Emergency Department (ED) with chest pain. Females were less likely to be diagnosed with MI, less likely to undergo diagnostic cardiac catheterization within seven days, and less likely to use evidence-based cardiac medications, even when having cardiac chest pain and cTn levels > 99th percentile. However, they had the highest one-year MACE rate. The higher burden of comorbid conditions seemed to be the driver of the higher MACE rate.