Syme C, et al. - Given the existence of many sex differences in mechanistic pathways that raise blood pressure (BP) in overweight/obesity and their possible consequences leading to sex-specific pattern of BP hemodynamics, researchers examined a population-based sample of middle-aged adults (36–65 years) for this possibility. The sample (n = 618) was comprised of 289 males and 329 females; of these, 79% of males and 66% of females were overweight. Overweight/obese individuals displayed clear sex differences in BP hemodynamics. Total peripheral resistance was the main determining factor of higher BP in males (49% vs only 35% in females), while in females stroke volume was the main determining factor of higher BP (51% vs only 35% in males). Normal-weight individuals, in whom the main determinant of higher BP was total peripheral resistance in both sexes, had no such differences.