Garcia R, Zigler JE, Radcliff KE, et al. - A prospective, randomized, multicenter IDE was conducted to compare the 7-year safety and efficacy of the activL artificial disc with ProDisc-L total disc replacement (TDR) in the treatment of patients with symptomatic single-level lumbar degenerative disc disease (DDD). Researchers included a sum of 206 individuals who had undergone single-level lumbar arthroplasty with either Activ L or Prodisc L. For lumbar DDD, long-term evidence supports TDR as safe and efficacious treatment. The outcomes illustrated the short-term benefits of TDR are maintained at 7 years, with patients no longer requiring narcotic use. In comparison with the first-generation TDR (ProDisc-L), the next generation activL Artificial Disc is more effective at preserving range of motion and offers an improved safety profile. They found similar other primary and secondary outcomes between disc designs.