Xiao XH, et al. - In patients with hyperthyroidism before and after methimazole treatment, researchers evaluated if serum zinc-α2-glycoprotein (ZAG), a recently characterized adipokine synthesized and secreted mainly by adipose tissues and liver, is associated with thyroid hormones (TH) and lipid profile. Study participants included 120 newly diagnosed with overt hyperthyroidism and 122 healthy control subjects. Of these, 39 patients with hyperthyroidism received methimazole treatment as a follow-up study for 2 months. Investigators found that serum ZAG levels were higher in patients with hyperthyroidism. Serum ZAG levels were reduced and the decline was related to decreased free T3 (FT3), free T4 (FT4) and increased total cholesterol (TC) levels after methimazole treatment. ZAG may be involved in the pathogenesis of lipid metabolism disorder in patients with hyperthyroidism.