Morikawa N, Bancks MP, Yano Y, et al. - Researchers ascertained gender-specific serum urate trajectories using SAS PROC TRAJ using serum urate measurements collected at baseline and 10, 15, 20 years after baseline from 3563 CARDIA (Coronary Artery Risk Development in Young Adults) participants (mean age 25.1±3.6 [18–30] years at baseline [year 0, 1985–1986]; 46.3% Black; 56.1% female). Hazard ratios for incident cardiovascular disease (CVD) events (coronary heart disease, heart failure, and stroke) occurring after the year 20 exam through 2017 were estimated. This study’s findings reveal that high-increasing serum urate trajectory during young adulthood was associated with incident CVD by middle age, and the association may be explained by blood pressure levels during the exposure period.