Loehrer E, et al. - Among patients with primary esophageal adenocarcinoma (EA) (n=476) from Massachusetts General Hospital, researchers examined the link between serum 25-Hydroxyvitamin D (25(OH)D) levels and overall survival (OS) time. Across quartiles of 25(OH)D levels, the difference in survival curves was tested by using logrank tests. Adjusted hazard ratios were estimated using Cox modeling. Across quartiles of 25(OH)D, they found no difference in survival. With regard to the hazard of mortality, no difference was evident between the highest quartile of 25(OH)D and any other quartile, on adjusting for confounders. When accounting for race or time between diagnosis and blood draw, consistent results were reported in sensitivity analyses. Moreover, no evidence of interaction between 25(OH)D and clinical stage or BMI on OS was found. Findings revealed no link between serum level of 25(OH)D near time of diagnosis and OS in EA patients.