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Serum haptoglobin levels are associated with renal function decline in type 2 diabetes mellitus patients in a Chinese Han population

Diabetes Research and Clinical Practice Nov 21, 2019

Huang Y, et al. - Researchers examined the role of serum haptoglobin (Hp) levels in the development and progression of diabetic kidney disease (DKD) in type 2 diabetes mellitus (T2DM) patients in a Chinese Han population. Using an enzyme-linked immunosorbent assay, they measured serum Hp levels in 233 participants suffering from T2DM for more than 10 years; of these, 118 individuals reported DKD (case) and 115 individuals had no DKD (control). Relative to controls, case group participants had significantly higher serum Hp levels. As per multiple linear regression analysis, there was a significant correlation of serum Hp levels with serum creatinine levels after adjusting for confounding risk factors. Findings support the possible utility of serum Hp levels as a potential biomarker for the early diagnosis and monitoring of DKD in T2DM patients.
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