Wu Y, Qin J, He J, et al. - Given the contribution of angiogenesis to the progression of chronic obstructive pulmonary disease (COPD), researchers conducted this research investigating the value of endostatin, a member of endogenous antiangiogenic proteins, as a biomarker in COPD and its role in the angiogenesis of COPD. They recruited 100 stable COPD patients, 130 patients with acute exacerbation (AECOPD) and 68 healthy volunteers. Serum analysis revealed a significantly higher endostatin level in sera of stable COPD vs healthy control; the level was even more in AECOPD patients. Besides, a higher concentration of endostatin was observed in the circulation in stable COPD patients with frequent exacerbation (≥ 2 exacerbations per year) in the last 1 year vs patients with less exacerbation. In addition, there was a negative association of circulatory endostatin with forced expiratory volume in 1 s% predicted (FEV1%pre), an index of lung function in the stable COPD group. Findings here support the possible utility of endostatin as a biomarker for COPD and its association with lower lung function, exacerbation, and systemic inflammation. The potential contribution of endostatin to the pathogenesis of COPD is suggested.