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Serious adverse events significantly reduce patient-reported outcomes at 2-year follow-up: Nonoperative, multicenter, prospective NIH study of 105 patients

Spine May 26, 2018

Pugely AJ, et al. - Researchers assessed the effect of serious adverse events (SAEs) on patient-reported outcomes (PROs) in nonoperative management of Adult Symptomatic Lumbar Scoliosis (ASLS) as measured by Scoliosis Research Society-22 (SRS-22), Oswestry Disability Index (ODI), and Short Form-12 (SF-12) at 2-year follow-up. They analyzed the ASLS trial dataset to identify adult lumbar scoliosis patients electively choosing or randomly assigned to nonoperative treatment with minimum 2-year follow-up. SAEs were experienced in a high percentage of ASLS patients managed nonoperatively. Less improvement was seen in those patients who sustained a SAE.
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