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Seizure outcome and its predictors after frontal lobe epilepsy surgery

Acta Neurologica Scandinavica Sep 06, 2019

Samuel JP, Menon RN, Chandran A, et al. - In a sizeable cohort of patients, researchers examined the longitudinal outcome and predictors of seizure outcome following frontal lobe epilepsy (FLE, the second most commonly performed surgery after temporal lobectomy for drug-resistant focal epilepsy world over) surgery. The study sample consisted of 73 consecutive patients who had FLE surgery between January 1997 and May 2015 with a minimum follow-up of 1 year. Older age at surgery, longer duration of epilepsy, presence of interictal epileptiform discharges in postoperative EEG on 7th day, 3 months and 1 year were predictors of seizure recurrence on multivariate analysis. Duration of epilepsy of less than 2 years before surgery was a significant predictor for achieving seizure freedom [defined as an absence of seizures till the last follow-up] in subgroup analysis. These findings highlight early surgery in frontal lobe epilepsy for a better result. Postoperative EEG remained a good long-term predictor.
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