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SARS‐CoV‐2 viremia is associated with inflammatory, but not cardiovascular biomarkers, in patients hospitalized for COVID‐19

Journal of the American Heart Association Feb 22, 2021

Myhre PL, Prebensen C, Jonassen CM, et al. - Among consecutive, hospitalized patients with both laboratory‐confirmed infection with SARS‐CoV‐2 and symptoms of COVID‐19, researchers examined if and how SARS‐CoV‐2 RNA in plasma was associated with cardiovascular biomarkers. They obtained biobank plasma samples used to determine SARS‐CoV‐2 RNA and cardiovascular and inflammatory biomarkers in 123 patients at baseline and in 96 (78%) at day 3. At baseline, SARS‐CoV‐2 RNA was found in plasma from 48 (39%) patients. Analyses revealed correlation of SARS‐CoV‐2 viremia with elevated concentrations of inflammatory biomarkers, but not with cardiovascular biomarkers. In patients with viremia, an increase in NT‐proBNP and D‐dimer, but not in cardiac troponin T, was observed from baseline to day 3. Patients with viremia were more frequently male, had more diabetes mellitus, and lower oxygen saturation, as well as higher concentrations of interleukin‐6, C‐reactive protein, procalcitonin and ferritin, but similar levels of cardiac troponin T, N‐terminal pro‐B‐type natriuretic peptide, and D‐dimer vs patients without viremia.

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