Temilola DO, et al. - Whether salivary creatinine use affords a safe and non-invasive alternative for detecting patients with chronic kidney disease (CKD), was determined in this cross-sectional analysis performed at Tygerberg Hospital in Cape Town, including 230 patients, across all stages of CKD. Researchers performed creatinine analysis after obtaining saliva and serum samples and used Spearman’s correlation to determine the correlation. They noted that in all CKD stages, except for stage 1, linear regression analysis of serum and salivary creatinine for CKD patients was significant. For salivary creatinine, the area under the curve was 0.839. The categorization of patients as having CKD depending on estimated glomerular filtration rate (GFR) < 60 mL/min/1.73 m² was enabled by a cut-off value of 8.5 μmol/L, with sensitivity and specificity of 78.3% and 74.0%, respectively. Experts concluded that salivary creatinine holds potential as a non-invasive diagnostic tool for estimating GFR and recognizing patients with CKD.