Bècle C, Riche B, Rabilloud M, et al. - Given that one-year morbi-mortality following transcatheter aortic valve implantation (TAVI) is still high, and proper identification of prognostic factors may allow further outcome improvements, so, researchers assessed some prognostic factors in 1,425 patients post-TAVI which included demographic factors and comorbidities (age, male gender, glomerular filtration rate, and chronic obstructive pulmonary disease), cardiac function (left ventricular ejection fraction, pulmonary pressure, aortic gradient, dyspnea, and mitral regurgitation), and vascular factors (coronary artery disease, peripheral vascular disease (PVD), prior stroke, and thoracic aortic calcium –TAC– as evaluated by CT-scan). The occurrence of 375 (26.3%) deaths was reported during the study span, including 248 (17.4%) due to cardiovascular causes. Only two factors related to cardiovascular or all-cause mortality demonstrated significant alterations over time: dyspnea and PVD. Findings revealed that the detrimental impacts of vascular factors continued to be stable (TAC) or increased (PVD) over time. To achieve improved post-TAVI results, targeting these factors by specific measures is recommended.