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Risk stratification in patients with frequent premature ventricular complexes in the absence of known heart disease

Heart Rhythm Oct 05, 2019

Ghannam M, Siontis KC, Kim MH, et al. - Given that structural heart disease can be indicated by frequent premature ventricular complexes (PVCs), researchers assessed the prevalence of scarring detected by cardiac magnetic resonance imaging (DE-CMR) in patients with frequent PVCs without apparent structural heart disease. In patients with frequent PVCs and myocardial scarring, whether programmed ventricular stimulation holds value for risk stratification, was also investigated. Overall 272 patients were included, with mean age: 52 ± 15 years, ejection fraction (EF): 52 ± 12%, and 135 were males. They found an association between presence and amount of DE-CMR and risk of long term ventricular tachycardia (VT) independent of EF. Long-term follow-up revealed a positive predictive value of 71% and a negative predictive value of 100% yielded by programmed ventricular stimulation for VT. Among patients with frequent PVCs without apparent heart disease, those at risk of VT can be recognized via preprocedural cardiac DE-CMR and programmed ventricular stimulation.
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