Gupta-Wright A, et al. - Because HIV-associated tuberculosis (HIV/TB) is very common in hospitals in sub-Saharan Africa and is a major cause of morbidity and mortality, investigators desired to create and validate externally a tool using urinary lipoarabinomannan and other clinical variables available in high-burden settings that could predict which HIV-positive patients diagnosed with TB were at high risk of early mortality. Data from HIV-positive adults hospitalized in Malawi and South Africa and diagnosed with TB were utilized to create a simple clinical risk score to find patients with a 50% chance of death within 2 months. Between January 2013 and August 2015, 644 subjects were involved in the validation cohort. Researchers developed and externally validated a 6-factor clinical risk score capable of identifying those with the highest risk of early mortality among patients admitted to hospital in settings with high HIV/TB burden. This score could be a beneficial clinical and research tool and could be beneficial in identifying patients who would gain the most from adjunctive mortality reduction interventions.