Tao X, et al. - Given the reporting of the highest-burden of sexually transmitted infections (STIs) among young people aged less than 25 years in the United States, researchers aimed at characterizing patients aged 15–24 vs patients ≥ age 25 utilizing a database of first visits to two STI clinics in Baltimore, USA from 2011 to 2016. In women, gonorrhea (GC), trichomonas, or early syphilis (ES) and in men, non-gonococcal urethritis, GC, Chlamydia, and ES defined acute STI (aSTI). They analyzed 15,463 first visits for patients < 25 and 25,203 for patients ≥ 25. Compared with participants ≥ 25, those < 25 were more likely to be Black and less likely to self-identify as straight. Despite reporting more partners, younger patients less frequently reported risk behaviors such as ‘Never’ using condoms, cocaine use, and sex with alcohol than older patients. By age and gender, differences were observed in predictors of aSTI risk. They recommend tailoring STI prevention messages and optimizing access to screening for young men and women, in order to address rising STI rates in this population.