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Risk factors for viridans group streptococcal bacteraemia in neutropenic and non-neutropenic patients: A single center case-case-control study

Open Forum Infectious Diseases Dec 14, 2017

Chiang AD, et al. - A case-case-control study was conducted by researchers to determine the risk factors for Viridans group streptococcal (VGS) among neutropenic and non-neutropenic patients. In the neutropenic group, only lower Absolute Neutrophil Count (ANC) nadir increased the risk for VGS bacteraemia, and vancomycin was protective. Researchers observed no independent association of other previously described factors (chemotherapy, radiation, oral conditions) related to neutropenia with VGS bacteraemia. In the non-neutropenic group, no tested clinical factors were predictive of infection. Results suggested anticipating VGS bacteraemia in profoundly neutropenic patients when making antimicrobial choices.
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