Acácio S, et al. - Researchers analyzed 916 Mozambican children with moderate-to-severe diarrhea (MSD) for mortality associated with diarrhea and risk factors for death. Among these, 90% (821/916) completed 60 days follow-up; there were 69 patients who died. They observed an increased risk of death in correlation to typical enteropathogenic Escherichia coli (typical EPEC) and Cryptosporidium but noted reduced risk in correlation to rotavirus infection. Co-morbidities like malnutrition, pneumonia/lower respiratory infection, invasive bacterial disease, presenting with lethargy or overt unconsciousness or wrinkled skin, and Cryptosporidium infection were the identified risk factors for death in the multivariate analysis. HIV was identified to be a significant risk factor for death when the analysis was restricted to those with available HIV results. The majority of diarrhea associated deaths in Mozambican children could be prevented with preventive strategies focused on Cryptosporidium, malnutrition and early identification and treatment of associated co-morbidities.