Stellefson M, et al. - Researchers identified subgroups of people with COPD [a leading cause of chronic disease-attributed death] who were at the highest risk of physical and mental distress in this secondary data analysis of 2016 Behavioral Risk Factor Surveillance System (BRFSS). For the past 14 days, most BRFSS respondents who reported a diagnosis of COPD experienced physical (53.76%) and/or mental (58.23%) distress. In females with COPD in the 45–64 age group, who were also identified as white and in the lower socioeconomic group, frequent physical and mental distress were more common. Respondents with intermediate to high-risk behaviors, intermediate to multiple comorbidities, limited access to health care, and intermediate to low use of preventive vaccinations were more likely than low-risk respondents to report frequent physical distress. Similarly, respondents with high-risk behaviors, intermediate to multiple comorbidities, and low use of preventive vaccines were more likely than the low-risk group to report frequent mental distress. According to findings, this analysis of the updated 2016 BRFSS data identified high-risk Americans with COPD who could benefit from disease management and interventions to promote secondary/tertiary health that could improve health-related quality of life.