Rhinovirus bronchiolitis, maternal asthma, and the development of asthma and lung function impairments
Pediatric Pulmonology Nov 27, 2020
Da Silva Sena CR, Morten M, Meredith J, et al. - In this prospective cohort study, researchers examined the combined impacts of hospitalization for rhinovirus (RV) positive bronchiolitis in infancy and a history of maternal asthma on the development of asthma at preschool age. The sample consisted of 139 preschool‐aged children, with a history of hospital admission for bronchiolitis in infancy, followed‐up to ascertain asthma and asthma‐like symptoms, skin prick allergy test positivity, and lung function measured pre-and post‐bronchodilator using impulse oscillometry. Compared with children with RV negative bronchiolitis and no maternal asthma history, those with a past hospitalization for RV positive bronchiolitis and a history of maternal asthma had the greatest prevalence and risk ratio for doctor‐diagnosed asthma, use of inhaled corticosteroids and short‐acting β‐agonists in the last 12 months. A subgroup of children with a high asthma burden is characterized by hospitalization for RV positive bronchiolitis in early life combined with a history of maternal asthma, whereas participants with only one of the two risk factors had an intermediate risk of asthma.
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