Blok F, et al. - In this retrospective study, researchers examined 527 BRCA1/2 carriers presenting for risk-reducing salpingo-oophorectomy (RRSO) to determine the prevalence of high grade serous carcinoma and serous tubal intraepithelial carcinoma (STIC) in these patients. For this purpose, they analyzed histology and performed immunohistochemistry (p53 & MIB-1). BRCA1 was seen in 68%, BRCA2 in 31.6%, and both mutations in 0.4% of overall cases included. A 2.3% (12/527) prevalence of high grade serous carcinoma was noted; 59% of tubal origin. In 0.8% (4/527), the presence of isolated STIC was reported. Peritoneal serous carcinoma was developed at >7 years later in 2 BRCA1 carriers with isolated STIC at RRSO. In those who presented for RRSO after the recommended age and had BRCA1/2 mutations, a more common prevalence of high grade serous carcinoma was found, and tubal origin was reported more often. Considering longer follow up of patients with STIC at RRSO was recommended.