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Retinopathy develops at similar glucose levels but higher HbA1c levels in people with black African ancestry compared to white European ancestry: Evidence for the need to individualize HbA1c interpretation

Diabetic Medicine Apr 29, 2020

Staimez LR, Rhee MK, Deng Y, et al. - Researchers conducted this retrospective cohort study to explore the correlation of HbA1c and glucose levels with incident diabetic retinopathy according to black African or white European ancestry. The sample consisted of 202,500 US Veterans with diabetes (2000–2014), measures included HbA1c, outpatient random serum/plasma glucose, and incident retinopathy [conversion from negative to ≥ 2 positive evaluations (ICD‐9 codes), without a subsequent negative]. According to results, HbA1c was 0.3% higher in black compared with white people, adjusting for baseline age, gender, BMI, eGFR, haemoglobin, and average systolic blood pressure and glucose. In individuals with black vs white ancestry, but with similar baseline glucose levels, the population incidence of retinopathy was correlated with higher mean baseline HbA1c. Because retinopathy occurs for a given level of average plasma glucose in black people at higher HbA1c levels, strategies may be required to individualize the interpretation of HbA1c measurements.

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